منابع مشابه
Trospium chloride: a quaternary amine with unique pharmacologic properties.
The mainstay of pharmacologic treatment of overactive bladder is anticholinergic therapy. Cholinergic blockade is efficacious in decreasing the symptoms of urgency, frequency, and urge incontinence, but also is associated with undesirable side effects such as dry mouth, blurred vision, constipation, and central nervous system side effects. The property of anticholinergic agents that has been as...
متن کاملPreparation and evaluation of Trospium chloride microspheres using chitosan polymer
In the present study, Chitosan microspheres containing Trospium chloride were prepared by coacervation phase separation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and b...
متن کاملTrospium chloride: over 20 years of clinical use
10.1586/14750708.3.2.215 © 2 Antimuscarinic drugs currently form the mainstay of pharmacotherapy for overactive bladder. Trospium chloride, an antimuscarinic with an unusual quaternary amine structure, has recently gained approval in the USA for the treatment of this condition. As a quaternary amine, trospium has pharmacological properties that are distinct from other available antimuscarinics ...
متن کاملTrospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?
OBJECTIVE To determine whether dose titration based on therapeutic response is superior to standard dosing of oral trospium chloride in patients with neurogenic detrusor overactivity and, moreover, to investigate the possible underlying causes of differences in efficacy at equal doses in some patients. PATIENTS AND METHODS Using a double-blind approach, two groups (standard dose and adjustabl...
متن کاملTrospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence
Trospium chloride is a quaternary ammonium compound, which is a competitive antagonist at muscarinic cholinergic receptors. Preclinical studies using porcine and human detrusor muscle strips demonstrated that trospium chloride was many-fold more potent than oxybutynin and tolterodine in inhibiting contractile responses to carbachol and electrical stimulation. The drug is poorly bioavailable ora...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2009
ISSN: 0108-7673
DOI: 10.1107/s0108767309093556